• 文章类型: Case Reports
    人类免疫缺陷病毒的流行在全球范围内呈上升趋势。药物相关的尿路结石通常是由用于治疗HIV阳性患者的药物引起的。我们介绍了一例HIV阳性的39岁男性,患有输尿管支架结壳和肾结石。使用一次性输尿管软镜进行输尿管碎石术。术后进展良好。一次性输尿管软镜可有效治疗HIV合并输尿管支架结壳。
    Human immunodeficiency virus prevalence was increasing worldwide. Medication-associated urinary calculi are very commonly caused by medications used to treat HIV-positive patients. We present a case of an HIV-positive 39-year-old male with ureteral stent encrustation and kidney stone. Ureterolithotripsy using a disposable flexible ureteroscope is performed. The postoperative evolution was favorable. The disposable flexible ureteroscope is effective in the treatment of HIV combined with ureteral stent encrustation.
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  • 文章类型: Journal Article
    尿路上皮癌的治疗随着腹腔镜或机器人手术等微创技术的引入而发展。挑战传统的开放手术方法,并导致非典型复发(AR)。AR包括端口部位转移和腹膜癌,然而,作者之间在精确分类方面仍然存在差异.AR的发病率在不同的研究中差异很大,在肌肉浸润性膀胱癌(MIBC)和上尿路上皮肿瘤(UTUC)中,范围从不到1%到超过10%。腹膜转移是MIBC患者中最常见的AR,而由于不同的手术方法,腹膜后转移在UTUC患者中普遍存在。AR表现的时间和生存结果与传统复发的时间密切相关,他们经常与之联系在一起。气腹逐渐被认为是ARs的病因,而与手术相关的危险因素越来越突出。目前与手术相关的主要原因包括手术期间肿瘤溢出和尿路侵犯,避免使用endo袋进行标本提取,和低手术经验。肿瘤分期等因素,组织学变异,和淋巴血管侵犯与ARs的风险相关,表明与肿瘤生物学密切相关。需要进一步的研究来更好地了解发病率,危险因素,特点,和AR的结果。
    The management of urothelial carcinoma has evolved with the introduction of minimally invasive techniques such as laparoscopic or robotic procedures, challenging the traditional approach of open surgery, and giving rise to atypical recurrences (ARs). ARs include port-site metastasis and peritoneal carcinomatosis, yet discrepancies persist among authors regarding their precise classification. Incidence rates of ARs vary widely across studies, ranging from less than 1% to over 10% in both muscle-invasive bladder cancer (MIBC) and upper tract urothelial tumor (UTUC). Peritoneal metastases predominate as the most common ARs in patients with MIBC, while retroperitoneal metastases are prevalent in those with UTUC due to differing surgical approaches. The timing of AR presentation and survival outcomes closely mirror those of conventional recurrences, with which they are frequently associated. Pneumoperitoneum has progressively been regarded less as the cause of ARs, while surgical-related risk factors have gained prominence. Current major surgical-related causes include tumor spillage and urinary tract violation during surgery, avoidance of endo bag use for specimen extraction, and low surgical experience. Factors such as tumor stage, histological variants, and lympho-vascular invasion correlate with the risk of ARs, suggesting a close association with tumor biology. Further studies are required to better understand the incidence, risk factors, characteristics, and outcomes of ARs.
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  • 文章类型: Journal Article
    背景和目的:这项研究评估了通过将球囊导管通过猪尾肾造口术引流导管插入球囊导管而形成的单通路途径联合尿路改道的有效性和安全性。通过这种方法,我们的目标是为输尿管漏患者提供一种替代方案,这些患者是不理想的手术选择.材料和方法:这项回顾性研究包括9例患者(其中8例为双侧病例,1例为单侧病例,总计17例),在2023年9月至2024年3月期间接受了手术。该方法涉及经皮进入骨盆系统,通过猪尾肾造口术导管插入4-FrenchFogarty球囊导管,并在输尿管近端或中段充气。结果:17例均获得技术成功,无重大并发症。该程序有效缓解了大多数患者与尿漏相关的症状。然而,5例(29.4%)发生球囊导管显著放气,三个(17.6%)经历完全通货紧缩。在这五个案例中,最终气球尺寸为5.81毫米(范围:0-8.9毫米),确认从手术前到手术后大小减少了25.0%。输尿管闭塞平均28.3d(范围:8-57d)。所有患者在暂时性输尿管闭塞期间症状缓解。除了两名失去随访的患者,3例患者仅出现PCN症状改善,4例患者在球囊导管拔除之前或之后接受了瘘管手术闭合.结论:本研究证实该方法是安全有效的。
    Background and Objectives: This study evaluated the efficacy and safety of temporary ureteral occlusion combined with urinary diversion using a single-access route created by inserting a balloon catheter through a pigtail nephrostomy drainage catheter. With this approach, we aimed to offer an alternative for patients with ureteral leaks who are suboptimal surgical candidates. Materials and Methods: This retrospective study included nine patients (eight of which were bilateral cases and one was unilateral, totaling seventeen cases) who underwent the surgery between September 2023 and March 2024. The method involved gaining percutaneous access to the pelvicalyceal system, inserting a 4-French Fogarty balloon catheter through a pigtail nephrostomy catheter, and inflating the balloon at the proximal or mid-ureter. Results: All 17 cases achieved technical successful with no major complications. The procedure effectively relieved symptoms associated with urinary leakage in most patients. However, the significant deflation of the balloon catheter occurred in five cases (29.4%), with three (17.6%) experiencing complete deflation. In these five cases, the final balloon size was 5.81 mm (range: 0-8.9 mm), confirming a 25.0% decrease in size from pre- to post-procedure. Ureteral occlusion was 28.3 d long on average (range: 8-57 d). All patients experienced symptom relief during temporary ureteral occlusion. Except for two patients lost to follow-up, three patients showed symptom improvement with only PCN and four patients underwent surgical closure of the fistula tract before or after balloon catheter removal. Conclusions: This study confirms that this approach is safe and effective.
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  • 文章类型: Journal Article
    背景:保留肾脏手术在高危上尿路尿路上皮癌患者中的作用存在争议。本研究旨在评估高风险输尿管远端肿瘤患者机器人辅助输尿管远端切除术的肿瘤和功能结果。
    方法:本回顾性队列分析使用ROBUUST2.0多中心国际(2015-2022)数据集。根据手术类型将输尿管远端肿瘤的高危患者分为:机器人辅助的输尿管远端切除术或机器人辅助的肾输尿管切除术。对局部无复发生存率进行生存分析,无远处转移生存率,和总体生存率。在调整了高危预后组的临床特征后,绘制Cox比例风险模型以评估事件发生时间结局的重要预测因子。
    结果:总体而言,检索到477名患者,其中58例接受了机器人辅助的远端输尿管切除术和419例机器人辅助的肾输尿管切除术,分别,平均(±SD)随访29.6个月(±2.6)。两组在基线特征方面具有可比性。在生存分析中,在无复发生存率方面没有观察到显著差异(P=0.6),机器人辅助远端输尿管切除术和机器人辅助肾输尿管切除术之间的无转移生存率(P=0.5)和总生存率(P=0.7)。在Cox回归分析中,手术类型从来都不是肿瘤预后较差的重要预测指标.末次随访时,接受机器人辅助远端输尿管切除术的患者术后肾功能明显更好。
    结论:无复发生存率方面的结果相当,无转移生存率,机器人辅助的远端输尿管切除术和机器人辅助的肾输尿管切除术患者之间的总生存率,观察到前组术后肾功能保存较好。对于某些高危输尿管远端UTUC患者,应考虑保留肾脏手术作为潜在选择。
    BACKGROUND: The role of kidney-sparing surgery in patients with high-risk upper urinary tract urothelial carcinoma is controversial. The present study aimed to assess oncological and functional outcomes of robot-assisted distal ureterectomy in patients with high-risk distal ureteral tumors.
    METHODS: The ROBUUST 2.0 multicenter international (2015-2022) dataset was used for this retrospective cohort analysis. High-risk patients with distal ureteral tumors were divided based on type of surgery: robot-assisted distal ureterectomy or robot-assisted nephroureterectomy. A survival analysis was performed for local recurrence-free survival, distant metastasis-free survival, and overall survival. After adjusting for clinical features of the high-risk prognostic group, Cox proportional hazard model was plotted to evaluate significant predictors of time-to-event outcomes.
    RESULTS: Overall, 477 patients were retrieved, of which 58 received robot-assisted distal ureterectomy and 419 robot-assisted nephroureterectomy, respectively, with a mean (±SD) follow-up of 29.6 months (±2.6). The two groups were comparable in terms of baseline features. At survival analysis, no significant difference was observed in terms of recurrence-free survival (P=0.6), metastasis-free survival (P=0.5) and overall survival (P=0.7) between robot-assisted distal ureterectomy and robot-assisted nephroureterectomy. At Cox regression analysis, type of surgery was never a significant predictor of worse oncological outcomes. At last follow-up patients undergoing robot-assisted distal ureterectomy had significantly better postoperative renal function.
    CONCLUSIONS: Comparable outcomes in terms of recurrence-free survival, metastasis-free survival, and overall survival between robot-assisted distal ureterectomy and robot-assisted nephroureterectomy patients, and better postoperative renal function preservation in the former group were observed. Kidney-sparing surgery should be considered as a potential option for selected patients with high-risk distal ureteral UTUC.
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  • 文章类型: Journal Article
    确定可能有助于预测逆行肾内手术(RIRS)期间输尿管入路鞘(UAS)放置成功的放射学参数。该研究包括49名在RIRS中放置输尿管入路鞘失败的患者和49名在2023年1月至2023年12月之间成功放置的对照组患者。年龄,性别,体重指数(BMI),非对比计算机断层扫描(NCCT),比较两组患者的肾输尿管膀胱(KUB)片。测量骨盆入口的前后(ap)直径,骨盆出口前后径,棘突间距离直径取自非对比计算机断层扫描(NCCT),而通过肾输尿管膀胱(KUB)造影测量骨盆前后直径和骨盆外侧直径。两组之间的年龄没有显着差异,性别,身体质量指数,ap骨盆入口直径,ap骨盆出口,和棘突间距离直径。然而,在KUB射线照相上测得的骨盆ap直径和骨盆外侧直径值之间存在统计学上的显着差异。在KUBX射线照片中测量的骨盆直径和骨盆侧向直径的值可用于预测RIRC手术期间UAS通过的可能性。然而,需要对更大的患者群体进行进一步研究以确定临界值.
    To identify the radiological parameters which may help to predict the success of ureteral access sheath (UAS) placement during retrograde intrarenal surgery (RIRS).The study included 49 patients in whom failure ureteral access sheath placement in RIRS and 49 control group patients who were successfully placement between January 2023 and December 2023. The age, gender, body mass index (BMI), non-contrast computed tomography (NCCT), and kidney ureter bladder (KUB) radiographs were compared between the two groups. Measurements of the anteroposterior (ap) diameter of the pelvic inlet, anteroposterior diameter of the pelvic outlet, interspinous distance diameter were taken from non-contrast computed tomography (NCCT), while pelvic anteroposterior diameter and pelvic lateral diameter were measured from kidney ureter bladder (KUB) radiography. There were no significant differences between the groups in age, gender, body mass index, ap pelvic inlet diameter, ap pelvic outlet, and interspinous distance diameter. However, a statistically significant difference was found between the pelvic ap diameter and pelvic lateral diameter values measured on the KUB radiography. The values for pelvic ap diameter and pelvic lateral diameter measured in the KUB radiographs can be used to predict the likelihood of UAS passage during RIRC procedures. However, further studies with larger patient groups are needed to establish a cut-off value.
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  • 文章类型: Journal Article
    背景:上尿路尿路上皮癌(UTUC)是一种罕见的恶性肿瘤,通常每个泌尿科每年只有很少的新病例。在北欧国家,是否遵守欧洲泌尿外科协会(EAU)关于UTUC的指南是未知的。这项调查的目的是审查EAU准则的执行情况,北欧国家UTUC治疗的围手术期管理和组织。
    方法:对北欧国家进行根治性肾输尿管切除术(NU)的93家医院进行了电子调查。调查由57个主要问题组成,数据收集于12月1日之间,2021年4月23日,2022年。
    结果:总有效率为47/93(67%),完成率为98%。≥72%的参与中心采用了6名接受诊断实践的受试者中的5名。NU作为高风险UTUC的治疗由37/47(79%)进行,91%包括膀胱袖套切除。
    结论:在北欧国家的诊断实践中,遵守EAU指南的程度很高,而疾病管理则不那么连贯。
    BACKGROUND: Upper tract urothelial carcinoma (UTUC) is a rare malignancy, with typically only few new cases annually per urological department. Adherence to European association of urology (EAU) guidelines on UTUC in the Nordic countries is unknown. The objective of this survey was to examine the implementation of EAU guidelines, the perioperative management and organization of the treatment of UTUC in the Nordic countries.
    METHODS: The electronic survey was distributed to 93 hospitals in the Nordic countries performing radical nephroureterectomy (NU). The survey consisted of 57 main questions and data was collected between December 1st, 2021 and April 23rd, 2022.
    RESULTS: Overall response rate was 47/93 (67%) with a completion rate of 98%. Five out of the 6 examined subjects on diagnostic practice are applied by ≥ 72% of the participating centers. NU as treatment for high-risk UTUC is performed by 37/47 (79%), and 91% include a bladder cuff excision.
    CONCLUSIONS: Adherence to EAU guidelines is high on diagnostic practice in the Nordic countries, whereas disease management is less coherent.
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  • 文章类型: Journal Article
    在结石形成者中已经描述了财务毒性,但是对于其原因以及与结石手术的关系知之甚少。因此,我们旨在从术前到术后时间点纵向描述结石形成者的财务应变标记。
    一项前瞻性队列研究于2022年1月至2023年4月进行。在接受选择性输尿管镜检查或经皮肾镜取石术之前,将患者纳入等待区。参与者在这个时间点和30天后完成了英联邦基金的两年期健康保险调查。从调查中预先选择了项目,以捕获由于医疗保健费用而导致的财务压力的标志。
    109名参与者报名参加。参与者大多数是白人(70%),受过大学教育(62%),和私人担保(72%)。尽管有这些传统的保护性社会人口特征,42%的患者在术前时间点报告了一些财务紧张的标志。医疗补助患者报告的经济压力更高(67%)。此外,46%的患者不知道他们的免赔额。反应率在术后30天很低(35%),但表明一些患者正在经历新的财务压力。
    本文显示,相当比例的结石患者甚至在手术之前就已经显示出医疗账单的财务压力,以及对他们可能产生的成本的理解不足。这使他们在术后容易遭受金融毒性,并强调在制定干预金融毒性的未来策略时了解所有促成因素的重要性。
    UNASSIGNED: Financial toxicity has been described in stone formers however little is understood regarding its causes and how it may relate to stone surgery. We therefore aimed to longitudinally describe markers of financial strain in stone formers from the preoperative to postoperative time points.
    UNASSIGNED: A prospective cohort study was conducted from January 2022 to April 2023. Patients were enrolled in the waiting area prior to undergoing elective ureteroscopy or percutaneous nephrolithotomy. Participants completed the Commonwealth Fund\'s Biennial Health Insurance Survey at this time point and at 30 days postop. Items were pre-selected from the survey to capture markers of financial strain due to healthcare costs.
    UNASSIGNED: One hundred nine participants were enrolled. Participants were a majority white (70%), college educated (62%), and privately ensured (72%). Despite these traditionally protective sociodemographic features, 42% of patients reported some marker of financial strain at the preoperative timepoint. Patients with Medicaid reported even higher financial stress (67%). Furthermore, 46% of patients did not know their deductible amount. Response rate was low at 30 days postop (35%) but suggested some patients were experiencing new financial strains.
    UNASSIGNED: This paper shows that a significant proportion of stone patients are already displaying markers of financial strain from healthcare bills even prior to surgery as well as poor understanding of the costs they may incur. This makes them vulnerable to experiencing financial toxicity postoperatively and emphasizes the importance of understanding all contributing factors when developing future strategies to intervene in financial toxicity.
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  • 文章类型: Case Reports
    一个9岁的孩子,斯派德,雌性家养短腿猫出现约1厘米大小的开放性伤口,暴露于左侧皮下输尿管旁路术(SUB)分流端口,该端口在出现前约11个月放置。在进行局部伤口处理并重新定位端口之前,尝试了两次初次闭合。在凹陷和重新定位之前,用聚己内酯和丙基甜菜碱伤口冲洗溶液局部冲洗暴露的端口,导致植入物的成功保留。在修订和省略五个月后,伤口完全覆盖和愈合。
    适当的局部治疗,对于SUB分流口挤压继发于泌尿道耐药局部感染的罕见并发症,重新定位和穿孔可能是一种成功的治疗选择。
    UNASSIGNED: A 9-year-old, spayed, female domestic shorthair cat presented with an open wound approximately 1 cm in size with exposure of the left subcutaneous ureteral bypass (SUB) shunting port that was placed approximately 11 months before presentation. Primary closures were attempted twice before local wound management with omentalisation and repositioning of the port. The exposed port was lavaged topically with a polyhexanide and propylbetaine wound irrigation solution before omentalisation and repositioning, resulting in successful retention of the implant. Five months after revision and omentalisation, there was complete coverage and healing of the wound.
    UNASSIGNED: Adequate topical treatment, repositioning and omentalisation could be a successful treatment option for the uncommon complication of SUB shunting port extrusion secondary to resistant local infection originating from the urinary tract.
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  • 文章类型: Systematic Review
    尿石症是一种常见疾病,影响全球约五分之一的人口。本系统综述探讨了炎症标志物对输尿管结石自发通过的预测作用。通过谷歌学者系统地搜索了这些文献,PubMed/MEDLINE,Cochrane图书馆,科学直接,CINAHL,WebofScience,和EMBASE数据库来识别直到2023年发表的论文。总的来说,确定了26篇文章,其中10人被排除在外。其余16篇论文报告了2,695名患者(男性1,723名,女性972名),1,654(61.37%)经历自发结石通过(SSP)和1,041(38.63%)没有经历它(非SSP)。位于输尿管上部的结石不太可能自发通过(SSP组152/959,15.94%与180/546,非SSP组为32.48%;p<0.001)。SSP组180/959(18.75%)存在输尿管中结石,而非SSP组84/546(14.52%)存在(p=0.0974)。输尿管下段结石更有可能自发通过,SSP组中627/959(63.31%),非SSP组中282/546(49.36%)(p<0.001)。大多数炎症标志物与SSP之间无显著相关性(p>0.05)。然而,与非SSP组相比,SSP组的降钙素原水平较低(132.7±28.1vs.分别为207±145.1)(p<0.001)。这项系统评价显示,除了降钙素原,大多数炎症标志物对输尿管SSP没有显著的预测能力.
    Urolithiasis is a common disease that affects approximately one-fifth of the global population. This systematic review explores the predictive role of inflammatory markers for the spontaneous passage of ureteral stones. The literature was systematically searched via Google Scholar, PubMed/MEDLINE, the Cochrane Library, Science Direct, CINAHL, Web of Science, and EMBASE databases to identify papers published until 2023. Overall, 26 articles were identified, of which 10 were excluded. The remaining 16 papers reported 2,695 patients (1,723 males and 972 females), with 1,654 (61.37%) experiencing spontaneous stone passage (SSP) and 1,041 (38.63%) not experiencing it (non-SSP). Stones located in the upper part of the ureter were less likely to pass spontaneously (152/959, 15.94% in the SSP group vs. 180/546, 32.48% in the non-SSP group; p < 0.001). Mid-ureteral stones were present in 180/959 (18.75%) of the SSP group compared to 84/546 (14.52%) of the non-SSP group (p = 0.0974). Lower ureteral stones were more likely to pass spontaneously, with 627/959 (63.31%) in the SSP group compared to 282/546 (49.36%) in the non-SSP group (p < 0.001). No significant correlation was found between most inflammatory markers and SSP (p > 0.05). However, procalcitonin levels were lower in the SSP group compared to the non-SSP group (132.7 ± 28.1 vs. 207 ± 145.1, respectively) (p < 0.001). This systematic review has revealed that except procalcitonin, most inflammatory markers do not offer significant predictive capability for ureteral SSP.
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  • 文章类型: Journal Article
    我们的目的是调查围手术期结局的差异,尤其是输尿管肠系膜狭窄,在机器人辅助根治性膀胱切除术(RARC)和回肠导管时接受了输尿管肠管支架吻合术的患者与未接受的患者之间。
    对我们的RARC数据库进行了回顾性审查(2009-2023年)。患者分为接受输尿管肠管支架吻合术的患者和未接受支架吻合术的患者。在年龄方面,以3(支架输尿管肠吻合)与1(无支架)的比例进行倾向评分匹配,性别,BMI,种族,美国麻醉医师协会评分,新辅助化疗,Charlson合并症指数,先前的放射治疗,既往腹部手术史,临床T3/临床T4分期,术前转移,术前肾积水.使用累积发生率曲线来描绘输尿管肠系膜狭窄,并使用Cox回归模型来识别与输尿管肠系膜狭窄相关的变量。
    488名患者接受了RARC,366人接受了输尿管肠管支架吻合术,122例患者接受了无支架入路。90天总体并发症没有显着差异,严重并发症,再入院,UTI,泄漏,肠梗阻(P>0.05)。在1年和2年,输尿管肠系膜狭窄的发生率分别为13%和18%。分别在支架组中,无支架组分别为7%和10%(P=0.05)。支架放置与输尿管肠系膜狭窄显着相关。
    无支架输尿管肠吻合与RARC和回肠导管后狭窄较少相关。
    UNASSIGNED: We aimed to investigate the differences in perioperative outcomes, especially ureteroenteric strictures, between patients who underwent a stented ureteroenteric anastomosis at the time of robot-assisted radical cystectomy (RARC) and ileal conduit vs those who did not.
    UNASSIGNED: A retrospective review of our RARC database was performed (2009-2023). Patients were divided into those who received stented ureteroenteric anastomosis vs those who did not. Propensity score matching was performed in the ratio of 3 (stented ureteroenteric anastomosis) to 1 (stent-free) in terms of age, gender, BMI, race, American Society of Anesthesiologists score, neoadjuvant chemotherapy, Charlson Comorbidity Index, prior radiation therapy, previous abdominal surgery history, clinical T3/clinical T4 stage, preoperative metastasis, and preoperative hydronephrosis. A cumulative incidence curve was used to depict ureteroenteric strictures and a Cox regression model was used to identify variables associated with ureteroenteric strictures.
    UNASSIGNED: Four hundred eighty-eight patients underwent RARC, 366 individuals underwent a stented ureteroenteric anastomosis, and 122 patients underwent a stent-free approach. There was no significant difference in 90-day overall complications, high-grade complications, readmissions, UTIs, leakage, and ileus (P > .05). Ureteroenteric strictures occurred at a rate of 13% and 18% at 1 and 2 years, respectively in the stented group, vs 7% and 10% in the stent-free group (P = .05). Stent placement was significantly associated with ureteroenteric strictures.
    UNASSIGNED: Stent-free ureteroenteric anastomosis was associated with fewer strictures following RARC and ileal conduit.
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